Cisplatin pten

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August undefined, 2024

WebMar 22, 2024 · Diaminodichloroplatinum (cisplatin, DDP) is one of the most effective and widely used DNA-damaging anticancer drugs used for the treatment of various human malignancies including NSCLC [ 4 ]. However, NSCLC patients who are initially sensitive to cisplatin often develop drug resistance, leading to chemotherapy failure [ 5 ]. WebCisplatin / pharmacology Cyclin-Dependent Kinase Inhibitor p27 / metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / …

Cisplatin and phenanthriplatin modulate long-noncoding RNA …

WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … WebMay 10, 2024 · Although cisplatin (Cis) is an effective chemotherapeutic agent in treatment of various cancers, its adverse effect of nephrotoxicity limits the clinical application. Remote ischemic preconditioning (RIPC) is a strategy to induce resistance in a target organ against the oxidative stress and injury by applying transient, brief episodes of ischemia. the hermitage hotel bournemouth tripadvisor

Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic …

WebMay 10, 2013 · PTEN is found to be either inactivated or mutated in various human malignancies. In the present study, we have investigated the regulation of PTEN during cisplatin induced apoptosis in A2780, A270-CP (cisplatin resistant), OVCAR-3 and SKOV3 ovarian cancer cell lines. Methods: Cells were treated with 10μM of cisplatin for 24h. WebApr 13, 2024 · HIGHLIGHTS who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic … Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and … WebThis is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4), which are tumor suppressors involved in apoptosis, cell transformation, invasion, and tumor progression . the hermitage hunter valley

Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects

Cisplatin pten

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebMay 10, 2013 · Cisplatin treatment promotes phosphorylation of AKT. PTEN is known as a negative regulator of AKT phosphorylation. The phosphorylation of AKT was analyzed … WebPTEN is a tumor-suppressor gene deactivating PI3K downstream of EGFR signaling. We hypothesize that PTEN-deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib).

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WebSpiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or … WebDec 14, 2015 · Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a fundamental role in the regulation of the cell …

WebCisplatin inhibited Akt phosphorylation and activation in OVCAR-3 cells but not in OVCAR-3/CDDP cells. The specific PI3K inhibitors LY294002 and wortmannin sensitized OVCAR-3/CDDP cells to cisplatin-induced apoptosis and decreased cell viability. WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …

WebApr 5, 2013 · In addition, miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN) and activation of Akt pathway. Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival. WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …

WebJan 12, 2024 · Cervical cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely utilized in locally advanced cervical cancer patients. However, resistance has been the major limitation. In this study, we found that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) was downregulated in cisplatin …

WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … the beat bookshop prahranWebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ... the beat birminghamWebApr 10, 2024 · Indeed, PTEN serves as a dual-specific phosphatase that suppresses cell proliferation and induces apoptosis and cell cycle arrest via repressing PI3K/Akt signaling mechanisms [208]. Zheng et al. revealed that miR-24 increases the chemoresistance of human TSCC cell lines to cisplatin by downregulating PTEN [209]. the beat book shopWebPRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Data files. Show entries ... neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing … the beat bluffs omnisphereWebJul 15, 2024 · Currently; cisplatin has been widely used to treat solid tumors including lung cancer ( Dasari and Tchounwou, 2014, Galluzzi, 2012 ). However, many patients acquire … the hermitage hotel bournemouth restaurantWebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. However, either resistance to cisplatin or multi-drug resistance (MDR) to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer. the hermitage clubhouseWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … the beat blacksburg