Web2 aug. 2012 · The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. Web5 mei 2016 · ASGR1 has long been recognized as a hepatic surface marker (Ashwell and Morell, 1974; Schwartz et al., ... Detection of circulating tumor cells in hepatocellular carcinoma using antibodies against asialoglycoprotein receptor, carbamoyl phosphate synthetase 1 and pan-cytokeratin. PLoS ONE 9, e96185 10.1371/journal.pone.0096185 ...
Asialoglycoprotein Receptor Deficiency in Mice Lacking the …
Web1 jul. 1995 · Transport of macromolecules into the cell by receptor-mediated endocytosis follows a complex series of intracellular transfers, passing through distinct environments. … The asialoglycoprotein receptors (ASGPR) are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are integral membrane proteins and are located on mammalian hepatocytes (liver cells), … Meer weergeven The asialoglycoprotein receptor was first characterized in 1968 by Morell et al. and was the first mammalian lectin identified. The researchers transferred radioactively-labeled ceruloplasmin that had undergone a reaction … Meer weergeven • Asialoglycoprotein+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Meer weergeven Asialoglycoprotein receptors function to catabolize galactosyl and N-acetylgalactosaminyl-containing substrates. More specifically, in most mammals, … Meer weergeven The human asialoglycoprotein receptors composed of two units, H1 and H2. Each of these units have their N-terminus within the cytoplasm of a liver cell, and a carbohydrate recognition domain (CRD) on the extracellular side. The CRD functions to … Meer weergeven incentives from nc greenpower
Hepatic asialoglycoprotein receptor-mediated binding of …
Web10 jun. 2024 · Trivalent N-acetyl-D-galactosamine (GalNAc) is known to be a high-affinity exogenous ligand against the asialoglycoprotein receptor (ASGPR), which is highly expressed on hepatocytes. In this study, we report that the kinetics of the hepatic uptake process between the two types of targeting pathways are different. Web10 apr. 2015 · The asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally on extra-hepatic cells. This makes it specifically attractive for receptor-mediated drug delivery with minimum concerns of toxicity. ASGPR facilitates internalization by clathrin-mediated endocytosis and exhibits high affinity for … incentives form new build